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Why, what and when to adapt in clinical trials

Brannath, Werner

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs.

With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages.

Group Sequential and Confirmatory Adaptive Designs in Clinical Trials - Semantic Scholar

This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population. Essentially, this adaptive methodology was introduced in the s.


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Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial.

Werner Brannath

With these designs, interim analyses are performed in order to stop the trial prematurely under contr Phrase Searching You can use double quotes to search for a series of words in a particular order. Wildcard Searching If you want to search for multiple variations of a word, you can substitute a special symbol called a "wildcard" for one or more letters.

Are you adaptable? Overview of adaptive clinical trial design

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